Chinese scientists have found that the main incentive for gastric cancer
Recently, the Chinese Academy of Sciences, Kunming Institute of Zoology, according to the latest research shows the answer, the researchers in the molecular pathology of gastric cancer research in the new progress
Found a lack of protease receptor is the main reason leading to gastric cancer.
China is a high incidence of gastric cancer, detected each year, about 400,000 patients with gastric cancer, gastric cancer accounts for the number of the world about 40%, gastric cancer mortality rate is 4-8 times that of developed countries in Europe and America.
Previously, the medical profession agreed that, Helicobacter pylori infection,Life emotional stress, unhealthy eating habits, preferences, such as smoked, high salt, spicy food and alcohol, would undermine and damage the gastric mucosa, causing gastritis, ulcers and other diseases, lead to a high risk of gastric cancer. But the exact cause is not clear.
Kunming Institute of Zoology, Chinese Academy of Sciences researcher Zhang Yun and Zhang Yong,
Dr. Yu Guoyu and other researchers found that protease activated receptor 4 (PAR4 receptor) is widely expressed in gastric mucosa, in gastric mucosal protection and injury repair, In gastric cancer have a positive effect.
Dr. Yu Guoyu and other researchers found that protease activated receptor 4 (PAR4 receptor) is widely expressed in gastric mucosa, in gastric mucosal protection and injury repair, In gastric cancer have a positive effect.
Researchers further with the First Affiliated Hospital of Kunming Medical College, co-
The use of molecular biology,cell biology and clinical pathology research techniques that gastric mucosal injury and repair of the "intermediary" - PAR4 receptors in gastric cancer patients was significantly decreased, the absence of lymph node metastasis of gastric cancer, poorly differentiated degree of correlation; PAR4 receptor gene promoter hypermethylation is causing the main reason for the lack of receptor expression, revealing unhealthy living habits and environmental factors important in the pathogenesis of gastric cancer in the inducement.
Researchers said, the results of human gastric mucosa protection for in-depth analysis, gastric injury repair and the physiological and pathological mechanisms provides new perspectives and clues, process for clinical pathology and prognosis of gastric cancer/stomach cancer detection provides new possibilities.
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